Changing things up helps any creative endeavor. Many graphic designers, myself included, have a strong tendency to keep type, images and everything in between strictly glued to the invisible grid that is ingrained in each of us. Keeping all type horizontal, right justified, and images or ornamentation all within the “box” has been done to death. Don’t get me wrong, the grid is not a bad thing and usually allows for high readability and great organization. I am certainly not suggesting to use an organic-shaped presentation for your next budget meeting. I do think that allowing your mind to think outside the grid will lead your designs to a better place. Simple things such as a slight angle on your header, titles turned vertically, or using organic shapes can all give your layout the edge that it might be missing.
Some examples of not-so-boxed-in sites can be found here