I have recently come to the understanding that Designers today, being able to use technology to our advantage and create outrageous designs completely on the computer and then having to print them and be completely disappointed by it, face a great challenge when it comes to color. there are two categories of colors: additive color process, which is used in the digital process like in Indesign or any other software and subtractive color process, which we deal with when we print out design on a paper. Not only we have to worry about our reader’s individual visual acuity but also be mindful of how two color systems will work together in a harmonious way and will not look off once printed on the paper. I am sure we all have been through this experience when everything looks great on the computer and once printed, it looks completely off.
hope this link helps with further answering your questions about it. I thought it was interesting: